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Review
. 1992;56(1):97-117.
doi: 10.1016/0163-7258(92)90039-3.

Beta A4 amyloid protein and its precursor in Alzheimer's disease

A I Bush  1 , K Beyreuther, C L Masters
Affiliations
Review

Beta A4 amyloid protein and its precursor in Alzheimer's disease

A I Bush et al. Pharmacol Ther. 1992.

Abstract

The beta A4 amyloid protein is now understood to play a pivotal role in the development of Alzheimer's disease. This protein is generated by the abnormal processing of the amyloid protein precursor, a large membrane glycoprotein. Insights into the mechanisms of this abnormal processing will give information relevant to the design of new therapeutic strategies for Alzheimer's disease.

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