Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2003 Jun;34(2):316-21.

Comparative clinical trial of two-fixed combinations dihydroartemisinin-napthoquine-trimethoprim (DNP) and artemether-lumefantrine (Coartem/Riamet) in the treatment of acute uncomplicated falciparum malaria in Thailand

S Krudsood  1 , K Chalermrut, C Pengruksa, S Srivilairit, U Silachamroon, S Treeprasertsuk, S Kano, G M Brittenham, S Looareesuwan
Affiliations
Clinical Trial

Comparative clinical trial of two-fixed combinations dihydroartemisinin-napthoquine-trimethoprim (DNP) and artemether-lumefantrine (Coartem/Riamet) in the treatment of acute uncomplicated falciparum malaria in Thailand

S Krudsood et al. Southeast Asian J Trop Med Public Health. 2003 Jun.

Abstract

An open randomized comparison of two-fixed dose artemisinin derivative-containing combination regimens was conducted in adults with acute uncomplicated multidrug resistant falciparum malaria in Thailand. DNP, a combination of dihydroartemisinin with napthoquine and trimethoprim developed recently in China, has been evaluated in China, Vietnam, Cambodia and Thailand. This study was performed to compare the safety, tolerability and efficacy of DNP and artemether-lumefantrine/Coartem. One hundred and thirty eligible uncomplicated falciparum malaria patients were enrolled into the study. Patients were randomly assigned in a 2:1 ratio into group A, which received DNP one tablet twice a day for one day; and group B, which received Coartem/Riamet four tablets twice a day for 3 days. The cure rates at 28-day were 99% and 97% in group A and group B, respectively. No serious adverse events occurred. We concluded that both DNP and Coartem/ Riamet were safe, well tolerated and highly efficacious in the treatment of acute uncomplicated falciparum malaria in Thailand.

PubMed Disclaimer

Figures

Fig 1
Fig 1
Mean parasitemia as compared to parasitemia at the onset of treatment.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Arnold K, Tran TH, Nguyen TC, Pham P. A randomized comparative study of artemisinin (quinghaosu) suppositories and oral quinine in acute falciparum malaria. Trans R Soc Trop Med Hyg. 1990;84:499–502. - PubMed
    1. Bakshi R, Hermelin-Fritz I, Gathmann I, Alteri E. An integrated assessment of the clinical safety of artemether-lumefantrine: a new oral fixed-dose combination antimalarial drug. Trans R Soc Trop Med Hyg. 2000;94:419–24. - PubMed
    1. Bunnag D, Harinasuta T. The current status of drug resistance in malaria. Int J Parasitol. 1987;17:169–80. - PubMed
    1. Bunnag D, Viravan C, Looareesuwan S, Karbwang J, Harinasuta T. Clinical trial of artesunate and artemether on multidrug-resistant falciparum malaria in Thailand: a preliminary report. Southeast Asian J Trop Med Public Health. 1991;22:380–5. - PubMed
    1. Hatz C, Abdulla S, Mull R, et al. Efficacy and safety of CGP 56697 (artemether and benflumetol) compared with chloroquine to treat acute faliparum malaria in Tanzanian children aged 1–5 years. Trop Med Int Health. 1998;3:498–504. - PubMed

Publication types

MeSH terms

LinkOut - more resources