Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Jan 15;281 ( Pt 2)(Pt 2):297-300.
doi: 10.1042/bj2810297.

Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells

K Schmidt  1 , E R Werner, B Mayer, H Wachter, W R Kukovetz
Affiliations

Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells

K Schmidt et al. Biochem J. .

Abstract

Inhibition of tetrahydrobiopterin (H4biopterin) biosynthesis in endothelial cells almost completely abolished the agonist-induced formation of endothelium-derived relaxing factor (EDRF) (NO). This inhibitory effect could be antagonized when H4biopterin biosynthesis was restored by activating a salvage pathway. These data indicate that the formation of EDRF strictly depends on the presence of intracellular H4biopterin, which, in addition to Ca2+, may represent a further physiological and/or pathophysiological regulatory of endothelial NO synthases.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Annu Rev Biochem. 1985;54:729-64 - PubMed
    1. J Biol Chem. 1989 Dec 5;264(34):20496-501 - PubMed
    1. Biochemistry. 1988 Nov 29;27(24):8706-11 - PubMed
    1. N Engl J Med. 1987 Jul 9;317(2):80-4 - PubMed
    1. Anal Biochem. 1980 Feb;102(1):176-88 - PubMed

Publication types