Review
[Pharmacokinetics of sulphonamides administered in combination with trimethoprim]
[Article in
Polish]
Affiliations
- PMID: 1298960
Item in Clipboard
Review
[Pharmacokinetics of sulphonamides administered in combination with trimethoprim]
[Article in
Polish]
Postepy Hig Med Dosw.
1992.
Abstract
Pharmacokinetic properties of sulfametrole, sulfamoxole, sulphamerazine, sulphadiazine, sulphamethoxazole and sulfamethopyrazine, i.e. the sulphonamides administered in combination with trimethoprim have been compared. From the pharmacokinetic point of view sulphadiazine seems to be the most optimal sulphonamide to apply jointly with trimethoprim. Some of long-acting sulphonamides like sulfamethopyrazine and sulfadimethoxine, used as components of above mentioned combinations, possess comparable clinical efficacy in spite of differences of their and trimethoprim half-lives.
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