[Changes in mechano-chemical properties, ATPase activity and structure of rat liver mitochondria under the effect of sodium fluoride]

Abstract

With elongation of periods of per oral administration of sodium fluoride into rats, in spite of the dose decrease, the activity of mitochondrial Mg2+-stimulated ATPase was increased. The capacity of the liver tissue mitochondria to swelling, contraction and to secondary swelling was altered. In acute and chronic experiments the distinct impairments in the ultrastructure of mitochondria of liver tissue cells were observed by means of electron microscopy; this demonstrated the possible correlation between structure and function of the organelles.