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Case Reports
. 1992;38(4):458-64.

[Esophageal tumor induction in monkeys]

[Article in Russian]
D Sh Beniashvili, V A Aleksandrov, K I Bardadze, V G Bespalov, A S Petrov, M S Sartaniia
  • PMID: 1300741
Case Reports

[Esophageal tumor induction in monkeys]

[Article in Russian]
D Sh Beniashvili et al. Vopr Onkol. 1992.

Abstract

The experiment used eight monkeys who had received such esophagotropic carcinogens as ethyl ester of N-nitrososarcosine and methyl-N-benzyl-N-nitrosamine. The animals were followed for 4 years. The former agent failed to induce cancer where as 3 monkeys who had received methyl-N-benzyl-N-nitrosamine in the total dose of 600, 625 and 720 mg developed esophageal tumors (papilloma-2 and squamous cell carcinoma-1) at days 527, 725 and 880 after the start of treatment. The biological and histological features of the tumors were close to those of their human counterparts.

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