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Comparative Study
. 1992 Apr;1(1):50-5.
doi: 10.1038/ng0492-50.

Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut

E J Neufeld  1 , D G Skalnik, P M Lievens, S H Orkin
Affiliations
Comparative Study

Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut

E J Neufeld et al. Nat Genet. 1992 Apr.

Abstract

Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified from HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda gt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats". As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development.

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