Microbial secondary metabolism: a new theoretical frontier for academia, a new opportunity for industry

Abstract

Microbial secondary metabolites are the low molecular mass products of secondary metabolism. They include antibiotics, pigments, toxins, effectors of ecological competition and symbiosis, pheromones, enzyme inhibitors, immunomodulating agents, receptor antagonists and agonists, pesticides, antitumour agents and growth promoters of animals and plants. They have a major effect on the health, nutrition and economics of our society. They have unusual structures and their formation is regulated by nutrients, growth rate, feedback control, enzyme inactivation and induction. Regulation is influenced by unique low molecular mass compounds, transfer RNA, sigma factors and gene products formed during post-exponential development. The synthases of secondary metabolism are often coded by clustered genes on chromosomal DNA and infrequently on plasmid DNA. The pathways of secondary metabolism are still not understood to a great degree and thus provide a new frontier for basic investigations of enzymology, control and differentiation. Cloning and expression of genes in industrial microorganisms offer new opportunities for strain improvement and discovery. Microbial metabolites have already established themselves as coccidiostats, immunosuppressants, antihelminthic agents, herbicides and cholesterol-reducing drugs. Great potential exists for the discovery of antiviral, antiparasitic, antitumour and pharmacological compounds and new agricultural products. The future for natural products is bright indeed.