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. 1992 Sep;2(1):56-60.
doi: 10.1038/ng0992-56.

Genetic dissection of autoimmune type I diabetes in the BB rat

H J Jacob  1 , A Pettersson, D Wilson, Y Mao, A Lernmark, E S Lander
Affiliations

Genetic dissection of autoimmune type I diabetes in the BB rat

H J Jacob et al. Nat Genet. 1992 Sep.

Erratum in

  • Nat Genet 1994 Jun;7(2):215

Abstract

The BB rat is among the best models of insulin-dependent diabetes mellitus--with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

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