Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1992;34(1-2):53-6.

Detection and molecular analysis of alpha and beta thalassaemia genes--recent developments in screening protocols

J Tan  1 , J S Tay, H B Wong
Affiliations
  • PMID: 1303468
Review

Detection and molecular analysis of alpha and beta thalassaemia genes--recent developments in screening protocols

J Tan et al. J Singapore Paediatr Soc. 1992.

Abstract

Molecular and non-molecular techniques have been utilized for the detection and characterisation of alpha- and beta-thalassaemia genes. Non-molecular techniques example, haematological indices and haemoglobin electrophoresis allow samples to be screened rapidly without the use of radionuclides but these techniques are unable to detect mutations at the gene level. Molecular analysis of alpha- and beta-globin genes either by Southern Blotting and radionuclides or DNA amplification using the polymerase chain reaction (PCR) allows detection of specific mutations and have enabled prenatal diagnosis of the thalassaemias.

PubMed Disclaimer

Publication types