Cell-mediated immune response in vitro. I. The development of suppressor cells and cytotoxic lymphocytes in mixed lymphocyte cultures
- PMID: 130426
Item in Clipboard
Cell-mediated immune response in vitro. I. The development of suppressor cells and cytotoxic lymphocytes in mixed lymphocyte cultures
J Immunol.
1976 Apr.
Abstract
During the in vitro development of cytotoxic lymphocytes (CL), suppressor cells also develop. Spleen cells or lymph node cells harvested from mixed lymphocyte cultures (MLC) on day 2 (day-2 MLC) and added to a fresh MLC suppressed the development of CL. This suppressive effect was sensitive to treatment with anti-theta and C. The suppressive effect of day-2 MLC was not due to cytotoxic effects nor to altered kinetics of the development of both suppressor cells and CL. Although CL develop from hydrocortisone-treated spleen cells, day-2 MLC of hydrocortisone-treated spleen cells did not suppress the development of CL. These studies suggest that suppressor cells and CL are derived from different T cell subpopulations.
Similar articles
-
Cell-mediated immune response in vitro. II. The mechanism(s) involved in the suppression of the development of cytotoxic lymphocytes.J Immunol. 1976 Dec;117(6):2226-32. J Immunol. 1976. PMID: 62810
-
Generation of cytotoxic T lymphocytes in vitro. VII. Suppressive effect of irradiated MLC cells on CTL response.J Immunol. 1976 Mar;116(3):716-23. J Immunol. 1976. PMID: 56399
-
Generation of cytotoxic T lymphocytes in vitro. VI. Effect of cell density on response in mixed leukocyte cultures.J Immunol. 1975 Dec;115(6):1688-94. J Immunol. 1975. PMID: 127012
-
Regulation of immune responses by suppressor T cells.Tohoku J Exp Med. 1976;5:91-143. Tohoku J Exp Med. 1976. PMID: 61102 Review. No abstract available.
-
Suppressor factor activity in cell-mediated immune responses.J Reticuloendothel Soc. 1978 Oct;24(4):417-25. J Reticuloendothel Soc. 1978. PMID: 152354 Review. No abstract available.
Cited by
-
PPD-induced blastogenesis is auto-regulated by suppressor cells generated in vitro.Experientia. 1979 Nov 15;35(11):1515-7. doi: 10.1007/BF01962819. Experientia. 1979. PMID: 159832
-
Recognition of polymorphic H-2 domains by T lymphocytes. I. Functional role of different H-2 domains for the generation of alloreactive cytotoxic T lymphocytes and determination of precursor frequencies.J Exp Med. 1981 Dec 1;154(6):1717-31. doi: 10.1084/jem.154.6.1717. J Exp Med. 1981. PMID: 6976406 Free PMC article.
-
Virus-replicating T cells in the immune response of mice. I. Virus plaque assay of the lymphocytes reactive to sheep erythrocytes.J Exp Med. 1977 Feb 1;145(2):390-404. doi: 10.1084/jem.145.2.390. J Exp Med. 1977. PMID: 64584 Free PMC article.
-
[Immunologic specificity, nature and properties of suppressor cells induced in mixed lymphocyte cultures].Biull Eksp Biol Med. 1980 Mar;89(3):315-8. doi: 10.1007/BF00834238. Biull Eksp Biol Med. 1980. PMID: 6446329 Russian.
-
Transfer of specific unresponsiveness to organ allografts by thymocytes. Specific unresponsiveness by thymocyte transfer.J Exp Med. 1979 May 1;149(5):1042-55. doi: 10.1084/jem.149.5.1042. J Exp Med. 1979. PMID: 376773 Free PMC article.