Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1953 Apr;97(4):525-52.
doi: 10.1084/jem.97.4.525.

Induced malignancy in cells from rat myocardium subjected to intermittent anaerobiosis during long propagation in vitro

H GOLDBLATT, G CAMERON

Induced malignancy in cells from rat myocardium subjected to intermittent anaerobiosis during long propagation in vitro

H GOLDBLATT et al. J Exp Med. 1953 Apr.

Abstract

In two strains of fibroblasts originating from fragments of myocardium from a 5 day old rat of the Slonaker-Addis strain, a strain known to develop tumors but rarely, abnormal morphologic alterations took place which eventuated in neoplastic changes. This happened only after repeated exposure of the cultures to an atmosphere of nitrogen (anaerobiosis) and did not occur in the control cultures of fibroblasts originating from the same rat heart, and grown continuously throughout the same period (2 (1/2) years) without exposure to nitrogen.

PubMed Disclaimer

References

    1. Proc Soc Exp Biol Med. 1951 Jul;77(3):572-8 - PubMed
    1. Cancer Res. 1949 Dec;9(12):728-35, illust - PubMed
    1. Ann Surg. 1945 May;121(5):700-3 - PubMed
    1. Proc Soc Exp Biol Med. 1951 Nov;78(2):540-3 - PubMed
    1. J Exp Med. 1938 Apr 30;67(5):691-708 - PubMed