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. 1953 Apr;97(4):525-52.
doi: 10.1084/jem.97.4.525.

Induced malignancy in cells from rat myocardium subjected to intermittent anaerobiosis during long propagation in vitro

H GOLDBLATT, G CAMERON

Induced malignancy in cells from rat myocardium subjected to intermittent anaerobiosis during long propagation in vitro

H GOLDBLATT et al. J Exp Med. 1953 Apr.

Abstract

In two strains of fibroblasts originating from fragments of myocardium from a 5 day old rat of the Slonaker-Addis strain, a strain known to develop tumors but rarely, abnormal morphologic alterations took place which eventuated in neoplastic changes. This happened only after repeated exposure of the cultures to an atmosphere of nitrogen (anaerobiosis) and did not occur in the control cultures of fibroblasts originating from the same rat heart, and grown continuously throughout the same period (2 (1/2) years) without exposure to nitrogen.

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