Review
doi: 10.1620/tjem.168.195.
Regulation of Myc: Max complex formation and its potential role in cell proliferation
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- PMID: 1306304
- DOI: 10.1620/tjem.168.195
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Review
Regulation of Myc: Max complex formation and its potential role in cell proliferation
Tohoku J Exp Med.
1992 Oct.
Free article
Abstract
The myc family of proto-oncogenes encodes short-lived nuclear phosphoproteins (Myc) involved in the control of cell proliferation and differentiation. Here we discuss the evidence for Myc's involvement in normal and abnormal cell proliferation and review recent information on Max, a novel protein that forms a sequence-specific DNA-binding complex with Myc. The properties of the Myc: Max heterodimeric complex suggest a model for how Myc may function in the cell.
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