Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1953 Jul;98(1):13-20.
doi: 10.1084/jem.98.1.13.

A histological study of infectious canine hepatitis by means of fluorescent antibody

D L COFFIN, A H COONS, V J CABASSO

A histological study of infectious canine hepatitis by means of fluorescent antibody

D L COFFIN et al. J Exp Med. 1953 Jul.

Abstract

A study of experimental infectious canine hepatitis in dogs by means of specific fluorescent antibody indicates that the intranuclear inclusions of this disease contain high concentrations of viral antigen. The increase in virus in the nuclei, as indicated by the accumulation of specific antigenic material, begins on the nuclear membrane and spreads from there to the interior of the nucleus, with the gradual formation of larger granules. Subsequently there appear the homogeneous inclusion bodies characteristic of this infection.

PubMed Disclaimer

References

    1. Am J Pathol. 1929 Jan;5(1):1-10.7 - PubMed
    1. Proc Natl Acad Sci U S A. 1951 Sep;37(9):565-9 - PubMed
    1. J Infect Dis. 1950 Jan-Feb;86(1):1-11, illust - PubMed
    1. J Exp Med. 1950 Jan 1;91(1):1-13 - PubMed
    1. J Am Vet Med Assoc. 1952 May;120(902):287-90 - PubMed