Hyperprolactinemia and steroid metabolism by rat mammary adenocarcinomas
- PMID: 130970
Item in Clipboard
Hyperprolactinemia and steroid metabolism by rat mammary adenocarcinomas
Cancer Res.
1976 Feb.
Abstract
The metabolism of both testosterone and dehydroepiandrosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin greater than 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin less than 60 ng/ml). The tumors associated with high prolactin significantly metabolized more testosterone to both 5alpha-dihydrotestosterone and 5alpha-androstanediol. The metabolism of dehydroepiandrosterone was similar in both groups of tumors. It is concluded that prolactin may differentially influence the metabolism of C19 steroids by rat mammary adenocarcinomas.
Similar articles
-
In vitro effects of prolactin upon testosterone metabolism by rat mammary adenocarcinomata.Eur J Cancer (1965). 1976 Sep;12(9):679-82. doi: 10.1016/0014-2964(76)90015-3. Eur J Cancer (1965). 1976. PMID: 823026 No abstract available.
-
Steroidogenesis in human and rat mammary adenocarcinoma.Br J Surg. 1972 Nov;59(11):904. Br J Surg. 1972. PMID: 4264188 No abstract available.
-
[The role of the hypophysis and the hypophyseal hormone prolactin in maintenance of the sexual specificity of the metabolism of testosterone and 5-alpha-dihydrotestosterone in rat liver slices].Hoppe Seylers Z Physiol Chem. 1975 Oct;356(10):1535-43. Hoppe Seylers Z Physiol Chem. 1975. PMID: 1213671 German.
-
Prolactin influences upon androgen action in male accessory sex organs.Adv Sex Horm Res. 1976;2:425-70. Adv Sex Horm Res. 1976. PMID: 189591 Review.
-
Human breast cancer: concerted role of diet, prolactin and adrenal C19-delta 5-steroids in tumorigenesis.Int J Cancer. 1992 Apr 1;50(6):854-8. doi: 10.1002/ijc.2910500603. Int J Cancer. 1992. PMID: 1532567 Review.
Cited by
-
Effects of serial passage on the endocrine response and steroid metabolism of a rat mammary carcinoma.Br J Cancer. 1980 Aug;42(2):326-30. doi: 10.1038/bjc.1980.234. Br J Cancer. 1980. PMID: 6775657 Free PMC article.
-
Hormonal status and steroid metabolism in two transplantable rat mammary tumours.Br J Cancer. 1979 Feb;39(2):200-4. doi: 10.1038/bjc.1979.32. Br J Cancer. 1979. PMID: 155467 Free PMC article. No abstract available.