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. 1992;122(3-4):399-409.
doi: 10.1007/BF01317202.

Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice

S Tracy  1 , N M Chapman, Z Tu
Affiliations

Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice

S Tracy et al. Arch Virol. 1992.

Abstract

A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequence and the predicted amino acid sequence of this clone have sites of divergence from 2 other completely sequenced CVB3 genomes although overall identity of the three CVB3 genomes is 99%.

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