Isocitrate dehydrogenase kinase/phosphatase: identification of mutations which selectively inhibit phosphatase activity

Abstract

Mutations in aceK, the gene encoding isocitrate dehydrogenase kinase/phosphatase, which selectively inhibit phosphatase activity have been isolated. These mutations yield amino acid substitutions within a 113-residue region of this 578-residue protein. These mutations may define a regulatory domain of this protein.