Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Apr 15;32(1):17-21.
doi: 10.1007/BF00569972.

Maternal and paternal origin of extra chromosome in trisomy 21

M Mikkelsen, A Hallberg, H Poulsen

Maternal and paternal origin of extra chromosome in trisomy 21

M Mikkelsen et al. Hum Genet. .

Abstract

Fluorescence markers were studied in 40 patients with Down's syndrome and their parents. In 11 cases maternal and in 5 cases paternal non-disjunction could be shown. The disjunctional event occurred in the first meiotic division in 5 maternal and in 2 paternal cases. A second division failure was found in 4 maternal and 2 paternal cases. In 3 cases the failure could either be of first or second meiotic division origin.

PubMed Disclaimer

References

    1. Hereditas. 1972;70(1):153-4 - PubMed
    1. Lancet. 1973 Mar 3;1(7801):487 - PubMed
    1. Humangenetik. 1975;27(4):303-7 - PubMed
    1. Chromosoma. 1970;30(2):215-27 - PubMed
    1. Lancet. 1963 Nov 23;2(7317):1121-2 - PubMed