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Case Reports
. 1992 Jan;31(1):34-8.
doi: 10.1002/ana.410310107.

Relapsing and remitting human immunodeficiency virus-associated leukoencephalomyelopathy

J R Berger  1 , C Tornatore, E O Major, J Bruce, P Shapshak, M Yoshioka, S Houff, W Sheremata, G F Horton, H Landy
Affiliations
Case Reports

Relapsing and remitting human immunodeficiency virus-associated leukoencephalomyelopathy

J R Berger et al. Ann Neurol. 1992 Jan.

Abstract

We describe a 33-year-old homosexual man with a steroid-responsive, remitting and relapsing leukoencephalopathy associated with recent human immunodeficiency virus type 1 (HIV-1) seroconversion. Biopsy of a parieto-occipital lesion revealed demyelination and astrogliosis with focal necrosis. Detailed investigations demonstrated no pathogens in the brain other than HIV-1. This patient illustrates that a neurological disorder clinically indistinguishable from multiple sclerosis may be the presenting manifestation of HIV-1 infection and may occur in the absence of clinically significant immunosuppression.

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