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Case Reports
. 1992 Mar;92(3):262-4.
doi: 10.1016/0002-9343(92)90075-m.

Glioblastoma, transforming growth factor-beta, and Candida meningitis: a potential link

P K Peterson  1 , C C Chao, S Hu, K Thielen, E G Shaskan
Affiliations
Case Reports

Glioblastoma, transforming growth factor-beta, and Candida meningitis: a potential link

P K Peterson et al. Am J Med. 1992 Mar.

Abstract

The development of Candida meningitis in a patient following partial resection of a glioblastoma raised suspicion that transforming growth factor (TGF-beta), an immunosuppressive cytokine known to be produced by this tumor, would be elevated in his cerebrospinal fluid (CSF). By using a highly specific bioassay, the concentration of TGF-beta was found to be 609 pg/mL, which was 10-fold greater than the mean CSF TGF-beta value in control subjects with no neurologic disease. Increased CSF TGF-beta levels were also detected in patients with other central nervous system (CNS) diseases: malignancies and AIDS dementia complex. These findings suggest that TGF-beta may play an immunopathogenetic role in the CNS.

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