Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Sep 24;125(38):11506-7.
doi: 10.1021/ja035121o.

1,4-palladium migration via C-H activation, followed by arylation: synthesis of fused polycycles

Marino A Campo  1 , Qinhua Huang, Tuanli Yao, Qingping Tian, Richard C Larock
Affiliations

1,4-palladium migration via C-H activation, followed by arylation: synthesis of fused polycycles

Marino A Campo et al. J Am Chem Soc. .

Abstract

A novel palladium migration/arylation methodology for the synthesis of complex fused polycycles has been developed, in which one or more sequential Pd-catalyzed intramolecular migration processes involving C-H activation are employed. The chemistry works best with electron-rich aromatics, which is in agreement with the idea that these palladium-catalyzed C-H activation reactions parallel electrophilic aromatic substitution.

PubMed Disclaimer