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. 1954 Mar;99(3):275-82.
doi: 10.1084/jem.99.3.275.

The existence of two forms of hypertensin

L T SKEGGS Jr, W H MARSH, J R KAHN, N P SHUMWAY

The existence of two forms of hypertensin

L T SKEGGS Jr et al. J Exp Med. 1954 Mar.

Abstract

Two types of hypertensin have been demonstrated by means of counter-current distribution. The first type is the product of the action of the enzyme, renin, upon its substrate and has been designated hypertensin I. It can be rapidly converted to a second approximately equally pressor compound, hypertensin II, apparently through the action of an enzyme in the plasma which requires halide or nitrate for activation. A highly purified preparation containing horse hypertensins I and II caused an elevation of blood pressure when injected into human beings.

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