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. 1992 Mar;12(3):601-3.
doi: 10.1016/0888-7543(92)90454-z.

Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16

J B Bateman  1 , I Klisak, T Kojis, T Mohandas, R S Sparkes, T S Li, M L Applebury, C Bowes, D B Farber
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Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16

J B Bateman et al. Genomics. 1992 Mar.

Abstract

The gene encoding the beta-subunit of rod photoreceptor cGMP phosphodiesterase (gene symbol PDEB, homolog of the mouse rd gene) is mapped to human chromosome 4 using somatic cell hybrids and further localized to the chromosome band 4p16 using in situ hybridization. A mutation in the mouse gene underlies the recessive trait of retinal degeneration in the rd mouse. Thus, the human homolog is a candidate for lesions causing retinal degeneration.

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