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. 1992 May;66(5):2709-16.
doi: 10.1128/JVI.66.5.2709-2716.1992.

Association of ICP0 but not ICP27 with purified virions of herpes simplex virus type 1

F Yao  1 , R J Courtney
Affiliations

Association of ICP0 but not ICP27 with purified virions of herpes simplex virus type 1

F Yao et al. J Virol. 1992 May.

Abstract

Recent studies have shown that ICP4, one of the major immediate-early proteins of herpes simplex virus type 1 is present within the tegument region of the virion (F. Yao and R. J. Courtney, J. Virol. 63:3338-3344, 1989). With monoclonal antibodies to two additional immediate-early proteins, ICP0 and ICP27, and Western blot (immunoblot) analysis, ICP0, but not ICP27, was also found to be associated with purified virus particles. In an effort to localize the ICP0 within the virion, purified virions were treated with trypsin in the presence and absence of detergent. The data suggest that ICP0 is located within the tegument region of the virion and is not localized in the envelope or within the nucleocapsid. The number of molecules of ICP0 per virion was estimated to be approximately 150.

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References

    1. J Virol. 1985 Dec;56(3):723-33 - PubMed
    1. Mol Cell Biol. 1985 May;5(5):957-63 - PubMed
    1. J Gen Virol. 1986 Nov;67 ( Pt 11):2365-80 - PubMed
    1. Mol Cell Biol. 1986 Jul;6(7):2371-81 - PubMed
    1. J Gen Virol. 1986 Dec;67 ( Pt 12):2571-85 - PubMed

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