[Multifocal neuropathy with persistent conduction block]

Abstract

Multifocal neuropathy, recently individualized, is characterized by progressive, asymmetrical lesions predominant in the upper limbs and associated with multifocal and persistent conduction block. Two clinical presentations have been identified: sensorimotor multineuritis and pure motor form which may mimick an anterior grey horn disease. The pathophysiology of the syndrome and the significance of its frequent association with the antibody to GM1 ganglioside remain debated. Various treatments have been tried with inconstant results.