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. 1992 Apr 17;35(8):1385-92.
doi: 10.1021/jm00086a006.

Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors

C Hubschwerlen  1 , P Pflieger, J L Specklin, K Gubernator, H Gmünder, P Angehrn, I Kompis
Affiliations

Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors

C Hubschwerlen et al. J Med Chem. .

Abstract

Substituted 4-quinolone- (1, A = CH) and 1,8-naphthyrid-4-one- (1, A = N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Pyrimido[1,6-alpha]benzimidazoles 11 have been found to be a new class of inhibitors of this enzyme. The design, synthesis, and biological activity of these compounds are reported.

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