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Review
. 1992:43:117-24.
doi: 10.1146/annurev.me.43.020192.001001.

Chronic granulomatous disease

M C Dinauer  1 , S H Orkin
Affiliations
Review

Chronic granulomatous disease

M C Dinauer et al. Annu Rev Med. 1992.

Abstract

Chronic granulomatous disease (CGD) encompasses a group of rare inherited disorders characterized by defects in a phagocyte-specific NADPH-oxidase complex that forms the superoxide radical during the respiratory burst. In this chapter, the protein components and cellular biochemistry of the oxidase are reviewed in light of recent genetic and biochemical studies of CGD. The classification and molecular genetic analysis of CGD is discussed. Finally, the use of recombinant human interferon-gamma as a new therapeutic agent for management of the disorder is reviewed.

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