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. 1976 Mar;5(2):191-4.
doi: 10.1111/j.1365-2265.1976.tb02832.x.

Increased somatostatin content of islets from streptozotocin-diabetic rats

Y C Patel, G C Weir

Increased somatostatin content of islets from streptozotocin-diabetic rats

Y C Patel et al. Clin Endocrinol (Oxf). 1976 Mar.

Abstract

Pancreatic islets were isolated from control and streptozotocin-diabetic rats. Somatostatin content as determined by radioimmunoassay was strikingly increased in the diabetic group. Immunoreactive insulin content was markedly reduced and glucagon was moderately increased. The mechanisms responsible for the somatostatin changes are unknown.

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