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Comparative Study
. 1992 Jun 1;175(6):1613-21.
doi: 10.1084/jem.175.6.1613.

Mls-1-like superantigen in the MA/MyJ mouse is encoded by a new mammary tumor provirus that is distinct from Mtv-7

C K Rudy  1 , E Kraus, E Palmer, B T Huber
Affiliations
Comparative Study

Mls-1-like superantigen in the MA/MyJ mouse is encoded by a new mammary tumor provirus that is distinct from Mtv-7

C K Rudy et al. J Exp Med. .

Abstract

Mls-1 is an endogenous superantigen that leads to in vivo deletion and in vitro stimulation of T cell receptor (TCR) V beta 6-, 7-, 8.1-, and 9-expressing cells. The MA/MyJ mouse deletes the identical set of TCR from its mature T cell repertoire; however, it does not contain Mtv-7, the murine mammary tumor provirus (MMTV), whose sag gene encodes Mls-1. Interestingly, the superantigen activity of this mouse strain segregates with a new mammary tumor provirus, Mtv-43, not seen in other inbred strains. The predicted amino acid sequence of the sag gene of Mtv-43 was compared with that of Mtv-7. Strikingly, the COOH terminus of the two molecules is very similar, while all other MMTV-encoded superantigens differ 100% in this segment.

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References

    1. Nature. 1991 Feb 7;349(6309):531-2 - PubMed
    1. Nature. 1991 Feb 7;349(6309):526-8 - PubMed
    1. Science. 1990 Feb 23;247(4945):964-7 - PubMed
    1. J Exp Med. 1990 Sep 1;172(3):807-13 - PubMed
    1. J Exp Med. 1989 Jun 1;169(6):2149-58 - PubMed

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