doi: 10.1016/s0166-4328(05)80127-5.
Failure of a chlordiazepoxide to reproduce the behavioral effects of muscimol administered into the basal forebrain
Affiliations
- PMID: 1317181
- DOI: 10.1016/s0166-4328(05)80127-5
Item in Clipboard
Failure of a chlordiazepoxide to reproduce the behavioral effects of muscimol administered into the basal forebrain
Behav Brain Res.
.
Abstract
Bilateral infusion of the GABAA-receptor agonist muscimol into the basal forebrain was previously found to impair visual conditional discrimination performance in rats. In order to examine whether the GABAergic input into the basal forebrain is active during performance of this task, the benzodiazepine receptor agonist chlordiazepoxide (15, 25, 40 micrograms/0.5 microliters/hemisphere) was bilaterally infused. Surprisingly, chlordiazepoxide did not affect performance. The impact of this result for the understanding of basal forebrain GABAergic functions is discussed.
Similar articles
-
Nucleus basalis magnocellularis and attention: effects of muscimol infusions.Behav Neurosci. 1993 Dec;107(6):1031-8. doi: 10.1037//0735-7044.107.6.1031. Behav Neurosci. 1993. PMID: 8136056
-
Disruptive effects of muscimol infused into the basal forebrain on conditional discrimination and visual attention: differential interactions with cholinergic mechanisms.Psychopharmacology (Berl). 1992;107(4):541-50. doi: 10.1007/BF02245269. Psychopharmacology (Berl). 1992. PMID: 1603898
-
The effects of compounds related to gamma-aminobutyrate and benzodiazepine receptors on behavioural responses to anxiogenic stimuli in the rat: extinction and successive discrimination.Psychopharmacology (Berl). 1986;88(3):285-95. doi: 10.1007/BF00180826. Psychopharmacology (Berl). 1986. PMID: 3008209
-
Intrahippocampal injections of benzodiazepine and muscimol impair working memory but not reference memory of rats in the three-panel runway task.Eur J Pharmacol. 1992 Aug 25;219(2):245-51. doi: 10.1016/0014-2999(92)90302-k. Eur J Pharmacol. 1992. PMID: 1330607
-
Anxiolytic effects of steroid hormones during the estrous cycle. Interactions with ethanol.Recent Dev Alcohol. 1995;12:243-59. doi: 10.1007/0-306-47138-8_16. Recent Dev Alcohol. 1995. PMID: 7624546 Review.
Cited by
-
Crossmodal divided attention in rats: effects of chlordiazepoxide and scopolamine.Psychopharmacology (Berl). 1994 Jun;115(1-2):213-20. doi: 10.1007/BF02244774. Psychopharmacology (Berl). 1994. PMID: 7862897
-
Dissociation between the attentional effects of infusions of a benzodiazepine receptor agonist and an inverse agonist into the basal forebrain.Psychopharmacology (Berl). 1995 Jul;120(1):99-108. doi: 10.1007/BF02246150. Psychopharmacology (Berl). 1995. PMID: 7480541
-
Neuronal mechanisms of the attentional dysfunctions in senile dementia and schizophrenia: two sides of the same coin?Psychopharmacology (Berl). 1994 May;114(4):539-50. doi: 10.1007/BF02244983. Psychopharmacology (Berl). 1994. PMID: 7855215 Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
