Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1992 Jun 4;357(6377):375-9.
doi: 10.1038/357375a0.

Proteolysis, proteasomes and antigen presentation

A L Goldberg  1 , K L Rock
Collaborators, Affiliations
Review

Proteolysis, proteasomes and antigen presentation

A L Goldberg et al. Nature. .

Abstract

Proteins presented to the immune system must first be cleaved to small peptides by intracellular proteinases. Proteasomes are proteolytic complexes that degrade cytosolic and nuclear proteins. These particles have been implicated in ATP-ubiquitin-dependent proteolysis and in the processing of intracellular antigens for cytolytic immune responses.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources