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Clinical Trial
. 1992 Apr 1;31(7):712-9.
doi: 10.1016/0006-3223(92)90281-4.

Alpha-2-adrenoceptor sensitivity in early alcohol withdrawal

J Balldin  1 , U Berggren, J Engel, G Lindstedt, A Sundkler, J Wålinder
Affiliations
Clinical Trial

Alpha-2-adrenoceptor sensitivity in early alcohol withdrawal

J Balldin et al. Biol Psychiatry. .

Abstract

Growth hormone (GH), blood pressure, and pulse rate responses to clonidine (100 micrograms IV) were studied three times during the first week of alcohol withdrawal in 19 alcohol-dependent patients. Fifteen healthy men were used as controls. The results suggest reduced sensitivity of the alpha-2-adrenoceptors involved in GH secretion for at least 1 week after the end of alcohol intake. In contrast, very short-lasting subsensitivity was found in the alpha-2-adrenoceptors regulating blood pressure.

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