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. 1976 May;34(5):451-4.

Islet cell membrane alteration by diabetogenic drugs

L Orci, M Amherdt, F Malaisse-Lagae, M Ravazzola, W J Malaisse, A Perrelet, A E Renold
  • PMID: 131879

Islet cell membrane alteration by diabetogenic drugs

L Orci et al. Lab Invest. 1976 May.

Abstract

Freeze-fracture of islets of Langerhans treated in vitro with diabetogenic agents alloxan and streptozotocin shows a decrease in the number of intramembranous particles of islet cell plasma membranes. This decrease is restricted to the membrane's A-fracture face and it can be prevented by experimental conditions which are known to counteract the toxic effect of both alloxan and streptozotocin.

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