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. 1992 Jun:73 ( Pt 6):1547-51.
doi: 10.1099/0022-1317-73-6-1547.

Cell growth effects of Epstein-Barr virus leader protein

G J Allan  1 , G J Inman, B D Parker, D T Rowe, P J Farrell
Affiliations

Cell growth effects of Epstein-Barr virus leader protein

G J Allan et al. J Gen Virol. 1992 Jun.

Abstract

B lymphoblastoid cell lines immortalized with P3HR1/633 Epstein-Barr virus (EBV), which has a deletion in the EBV nuclear antigen leader protein (EBNA-LP) gene, were transfected with a vector expressing wild-type EBNA-LP. The EBNA-LP transfectants grew out faster under G418 selection than control cells but expression of EBNA-LP made no significant difference to growth rate or saturation density of the resulting established cell lines. When the cells expressing EBNA-LP were allowed to grow to saturation and then diluted in fresh medium they underwent DNA synthesis more rapidly than control cultures.

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