Review
doi: 10.1016/0192-0561(92)90174-j.
Leukotriene B4 in the immune system
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- PMID: 1319964
- DOI: 10.1016/0192-0561(92)90174-j
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Review
Leukotriene B4 in the immune system
Int J Immunopharmacol.
1992 Apr.
Abstract
Leukotriene (LT) B4 is a biologically active molecule derived from arachidonic acid via the 5-lipoxygenase pathway. It mediates certain inflammatory and immunological reactions. The role of LTB4 in the immune system has been questioned since lymphocytes have been regarded to lack the enzymes involved in LTB4 formation. This review focuses on the recently described biosynthesis of LTB4 in B-lymphocytes and the effects of this compound on lymphocyte functions.
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