doi: 10.1084/jem.100.4.363.
The purification of hypertensin I
- PMID: 13201713
- PMCID: PMC2136385
- DOI: 10.1084/jem.100.4.363
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The purification of hypertensin I
J Exp Med.
.
Abstract
The purification of hypertensin I has been described. The final product which is four times as powerful a pressor agent as l-arterenol, is obtained with an over-all recovery of 40 per cent. The product consists of a single component in countercurrent distribution, having a nitrogen content of 15.97 per cent and a specific activity of 7050 Goldblatt units per mg. of N or 1125 units per mg. of solid. Acid hydrolysis and paper chromatography indicate in a preliminary fashion that there are about nine amino acids present in the intact polypeptide.
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