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. 1954 Oct 1;100(4):363-70.
doi: 10.1084/jem.100.4.363.

The purification of hypertensin I

L T SKEGGS Jr, W H MARSH, J R KAHN, N P SHUMWAY

The purification of hypertensin I

L T SKEGGS Jr et al. J Exp Med. .

Abstract

The purification of hypertensin I has been described. The final product which is four times as powerful a pressor agent as l-arterenol, is obtained with an over-all recovery of 40 per cent. The product consists of a single component in countercurrent distribution, having a nitrogen content of 15.97 per cent and a specific activity of 7050 Goldblatt units per mg. of N or 1125 units per mg. of solid. Acid hydrolysis and paper chromatography indicate in a preliminary fashion that there are about nine amino acids present in the intact polypeptide.

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