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. 1976 May 3;86(1):95-102.
doi: 10.1007/BF00304939.

Carcinogenic effects of different nitroso-compounds in Chinese hamsters. II. N-nitrosomorpholine and N-nitrosopiperidine

G Reznik, U Mohr, N Kmoch

Carcinogenic effects of different nitroso-compounds in Chinese hamsters. II. N-nitrosomorpholine and N-nitrosopiperidine

G Reznik et al. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. .

Abstract

A total of 320 Chinese hamsters (Cricetulus griseus) (CH) were subcutaneously (s.c.) treated with 1/5, 1/10, or 1/20 LD50 of N-nitrosomorpholine (NM) or N-nitrosopiperidine (NP). In the CH, NM and NP both produced up to a 100% rate of papillomas of the cheek pouch, tongue, pharynx, esophagus and forestomach. Occasionally squamous cell carcinomas also developed in these organs. A high rate of hepatomas was realized by NP.

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References

    1. Br J Cancer. 1976 Apr;33(4):411-8 - PubMed
    1. J Natl Cancer Inst. 1973 Oct;51(4):1295-301 - PubMed
    1. J Natl Cancer Inst. 1974 Jul;53(1):231-7 - PubMed

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