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. 1992;21(2):95-100.
doi: 10.1007/BF01836955.

Human papillomavirus in breast cancer

A Di Lonardo  1 , A Venuti, M L Marcante
Affiliations

Human papillomavirus in breast cancer

A Di Lonardo et al. Breast Cancer Res Treat. 1992.

Abstract

Histological sections from paraffin-embedded breast carcinoma and axillary lymph nodes were examined for the presence of human papillomaviruses by two different techniques: the polymerase chain reaction (PCR) and the in situ hybridization with biotin-labelled probes. By PCR we detected HPV 16 DNA sequences in 29.4% of breast tumours and in some metastatic lymph nodes, though we were unable to identify any HPV DNA sequences by in situ hybridization. These results suggest that HPV's could play a role in the genesis of breast neoplasia.

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