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. 1992 Mar;105(3):508-10.
doi: 10.1111/j.1476-5381.1992.tb09008.x.

The non-peptide NK1 receptor antagonist, (+/-)-CP-96,345, produces antinociceptive and anti-oedema effects in the rat

P J Birch  1 , S M Harrison, A G Hayes, H Rogers, M B Tyers
Affiliations

The non-peptide NK1 receptor antagonist, (+/-)-CP-96,345, produces antinociceptive and anti-oedema effects in the rat

P J Birch et al. Br J Pharmacol. 1992 Mar.

Abstract

The non-peptide NK1 receptor antagonist, (+/-)-CP-96,345, has been evaluated for antinociceptive activity in two well-characterized inflammatory pain models in the rat. (+/-)-CP-96,345 abolished carrageenin-induced mechanical hyperalgesia, significantly reduced carrageenin-induced paw oedema and attenuated the second phase of the formalin response. The results suggest that NK1 receptor activation occurs during the induction of inflammatory pain states in the rat.

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