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. 1992 Jul:73 ( Pt 7):1849-54.
doi: 10.1099/0022-1317-73-7-1849.

Identification of the glycoprotein H gene of murine cytomegalovirus

J Xu  1 , P B Dallas, P A Lyons, G R Shellam, A A Scalzo
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Identification of the glycoprotein H gene of murine cytomegalovirus

J Xu et al. J Gen Virol. 1992 Jul.

Abstract

Partial sequencing of the HindIII C fragment of murine cytomegalovirus (MCMV) revealed an open reading frame of 2172 nucleotides in length encoding a 724 amino acid protein with a predicted Mr of 80.4K. Analysis of the predicted amino acid sequence revealed homology with glycoprotein H (gH) from a number of other herpesviruses. MCMV gH showed strongest amino acid identity with human (H) CMV and human herpesvirus 6 gH, and less identity with the gH protein sequences of Epstein-Barr virus, varicella-zoster virus and herpes simplex virus type 1. The greatest identity between MCMV and HCMV gH occurs in the C-terminal region. The MCMV gH is characterized by having a 14 amino acid signal sequence, a 23 amino acid transmembrane region, a seven amino acid positively charged cytoplasmic anchor sequence and eight putative N-linked glycosylation sites. Comparison of MCMV gH with that of HCMV indicates that there are 12 conserved cysteine residues and three conserved potential N-linked glycosylation sites.

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