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Clinical Trial
. 1976 Apr 21;255(2):129-38.
doi: 10.1007/BF00558520.

Topical vitamin A acid in the treatment of acne vulgaris (a controlled multicenter trial)

M Gandola, G Argenziano, C Barba, R Bassi, M Binazzi, G Landi, L Levi, D Randazzo, F Serri, A P Villano
Clinical Trial

Topical vitamin A acid in the treatment of acne vulgaris (a controlled multicenter trial)

M Gandola et al. Arch Dermatol Res (1975). .

Abstract

A controlled non-blind multicenter trial was conducted in 211 acne patients to test the activity of topical retinoic acid against sulfur-resorcinol--salicylic acid and placebo. Uniform evaluation criteria were used. After 8 weeks' treatment in comparable groups of patients, retinoic acid proved to be superior to the standard and to the placebo. The difference was statistically significant. Side effects were present in a number of patients treated with the active substances and with the placebo (mainly erythema), but rarely was the treatment discontinued.

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