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. 1992:(202):67-72.
doi: 10.1111/j.1755-3768.1992.tb02171.x.

Reactive formation of hyaluronic acid in the rabbit corneal alkali burn

P Fagerholm  1 , T Fitzsimmons, A Härfstrand, M Schenholm
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Reactive formation of hyaluronic acid in the rabbit corneal alkali burn

P Fagerholm et al. Acta Ophthalmol Suppl (1985). 1992.

Abstract

The presence and distribution of reactively formed hyaluronic acid (HA) was assessed in the rabbit cornea following a penetrating alkali burn. The injury was inflicted by applying a round, 5.5 mm, filter paper soaked in 1 N NaOH centrally on the cornea for 60 seconds. Biochemical analysis revealed a significant increase of HA two weeks after injury, a peak concentration after 1 month, and a decrease again at three months. Histochemical analysis revealed the presence of hyaluronic acid in the healing epithelium, in the repopulating keratocytes/fibroblasts, and in the cells forming the retrocorneal membrane. Extensive amounts filled lacunae in the stroma as well as the spaces between collagen lamellae. A slow restoration of normal appearing corneal stroma took place at the periphery. Significant staining for HA in lacunae was present centrally in the wound after three months.

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