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. 1992 Sep;66(9):5598-602.
doi: 10.1128/JVI.66.9.5598-5602.1992.

Multimerization of ICP0, a herpes simplex virus immediate-early protein

J Chen  1 , C Panagiotidis, S Silverstein
Affiliations

Multimerization of ICP0, a herpes simplex virus immediate-early protein

J Chen et al. J Virol. 1992 Sep.

Abstract

ICP0, a herpes simplex virus immediate-early gene product, is a highly phosphorylated nuclear protein that is a potent activator of virus and host genes. Using biochemical and genetic assays employing plasmids encoding mutant forms of ICP0 and a recombinant adenovirus that expresses ICP0, we mutant forms of ICP0 and a recombinant adenovirus that expresses ICP0, we provide evidence that the protein multimerizes. Some mutant forms of ICP0 were transdominant and interfered with activation of a target reporter gene or with complementation of an ICP0-minus virus.

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References

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