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. 1976:Suppl 6:71-3.

Effects of streptozotocin added in vitro on insulin biosynthesis and release in isolated rat islets

A Maldonato, P Trueheart, A E Renold
  • PMID: 132395

Effects of streptozotocin added in vitro on insulin biosynthesis and release in isolated rat islets

A Maldonato et al. Horm Metab Res. 1976.

Abstract

The effect of different concentrations of streptozotocin was tested in vitro on isolated rat islets. The following parameters of islet-cell activity were measured: 1) incorporation of 3H-leucine into proinsulin and into total islet protein; 2) IRI release into the medium, and 3) islet proinsulin content. It appears from the preliminary results shown here that both insulin release and biosynthesis were decreased by streptozotocin in a way which was dose- and time-dependent.

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