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. 1992 Jun;29(6):687-92.
doi: 10.1093/jac/29.6.687.

Evaluation of temafloxacin in a rat model of intra-abdominal abscess

H Thadepalli  1 , M Hajji, V K Perumal, S K Chuah, S Gollapudi
Affiliations

Evaluation of temafloxacin in a rat model of intra-abdominal abscess

H Thadepalli et al. J Antimicrob Chemother. 1992 Jun.

Abstract

The in-vitro activity of temafloxacin, a new fluoroquinolone, was evaluated in an experimental model of intra-abdominal abscess in rats. Mixed aerobic-anaerobic infection was induced by intraperitoneal implantation of gelatin capsules containing Bacteroides fragilis, Escherichia coli, and sterile rat faeces. Temafloxacin was highly active with a 90.9% cure rate in comparison with no treatment (no cures; P less than 0.0001), and as active as a combination of clindamycin and gentamicin (100% cure rate; P greater than 0.05). Temafloxacin (12 mg/dose) gave rise to serum concentrations that exceeded the MIC values of both microorganisms for at least 8 h.

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