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. 1992 May;37(5):453-6.

Human papillomavirus-associated lesions of the vagina and cervix. Treatment with a laser and topical 5-fluorouracil

M Brodman  1 , P Dottino, F Friedman Jr, D Heller, I Bleiweiss, R Sperling
Affiliations
  • PMID: 1324311

Human papillomavirus-associated lesions of the vagina and cervix. Treatment with a laser and topical 5-fluorouracil

M Brodman et al. J Reprod Med. 1992 May.

Abstract

Twenty women with cervical and vaginal human papillomavirus-associated lesions were treated with CO2 laser ablation followed by eight weekly applications of 5-fluorouracil. Viral subtyping in a majority of patients and histology were obtained before and after treatment. After treatment 88% (15 of 17) had normal vaginal biopsies, and 59% (10 of 17) had normal cervical biopsies. There were no treatment failures with subtype 6/11 infection of the cervix or vagina. All the failures were with viral subtypes 16/18 and 31/35/51. The protocol was effective in treating patients with cervical and vaginal human papillomavirus-associated lesions.

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