Review
doi: 10.1016/0167-5699(92)90044-8.
Regulation of TCR alpha and beta gene allelic exclusion during T-cell development
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- PMID: 1324691
- DOI: 10.1016/0167-5699(92)90044-8
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Review
Regulation of TCR alpha and beta gene allelic exclusion during T-cell development
Immunol Today.
1992 Aug.
Abstract
Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha beta combination. How do T cells achieve this TCR allelic exclusion? This article discusses the configuration and expression of TCR alpha and beta genes in mature T-cell lines and TCR alpha beta transgenic mice, and proposes three nonexclusive models to account for the significant occurrence of T cells with two productive alpha gene rearrangements.
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