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. 1992 Sep;89(3):509-12.
doi: 10.1111/j.1365-2249.1992.tb06990.x.

Signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone

H S Anttila  1 , S Reitamo, M Ceska, M Hurme
Affiliations

Signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone

H S Anttila et al. Clin Exp Immunol. 1992 Sep.

Abstract

Previous studies have shown that IL-8 gene expression is enhanced by various stimuli, which induce different signal transduction pathways. A lipopolysaccharide (LPS)-induced pathway has been reported to be inhibited by glucocorticoids in monocytes. We have now examined the effect of dexamethasone on the LPS-induced and other signal transduction pathways leading to the production of IL-8 by human monocytes. Dexamethasone inhibited the production of IL-8 stimulated with a cyclic adenosine monophosphate analog or LPS. In contrast, dexamethasone had no significant effect on a phorbol ester (PMA)-stimulated IL-8 production. These results suggest that the signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone.

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