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. 1992 Apr 22;214(2-3):289-92.
doi: 10.1016/0014-2999(92)90133-o.

L-cysteine augments the vasorelaxation induced by sodium nitrite and SIN-1 but not that due to acetylcholine

P Arvola  1 , I Pörsti, P Vuorinen, H Huhtala, T Metsä-Ketelä, H Vapaatalo
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L-cysteine augments the vasorelaxation induced by sodium nitrite and SIN-1 but not that due to acetylcholine

P Arvola et al. Eur J Pharmacol. .

Abstract

The effects of 1 mM L-cysteine on sodium nitrite-, 3-morpholinosydnonimine (SIN-1)- and acetylcholine-induced relaxation and cyclic GMP accumulation were studied in isolated noradrenaline-precontracted rat mesenteric arterial rings. L-Cysteine augmented the relaxation and cyclic GMP increase induced by sodium nitrate and SIN-1 but not those induced by acetylcholine. The effects of L-cysteine on relaxation were independent of the presence of intact endothelium. The results suggest that L-cysteine protects exogenously released nitric oxide.

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